Apart from the creation of superbugs, overuse of antibiotics has negative consequences including killing many of our beneficial bacteria. In the grand scheme of things, little is known about the bacteria we live with, and how they individually as a species, and collectively in combinations forming biofilms, get affected by various exposures to our antibiotics. Insufficient research is being conducted to help us find the answers.
Some research has suggested that antibiotic use may play a role in conditions that lead to obesity, Type 1 Diabetes, inflammatory bowel disease, allergies and even asthma, a common chronic airway disorder. Patient populations suffering from all of these chronic diseases appear to be increasing in prevalence, but very little is being done to understand if anything in contributing to all of these conditions as a group instead of just individually.
In agriculture, antibiotics have been used as “growth promoters” enabling farmers to increase their livestock yield, as their animals can gain more weight with less food. The influence of these antibiotics on the livestock we eat is likely to have some impact on our own bodies but this field has not yet been adequately investigated primarily due to lack of financial motivation. In Europe, where usage of antibiotics in livestock as growth promoters has been banned, it was determined that the same dollars spent on extra food resulted in the same growth as yielded by the additional antibiotics.
Given that antibiotics are a critical part of our medicinal arsenal, it is not likely that antibiotics will be replaced any time soon. However, it is important to start asking the questions and dedicate more resources to learning more about how the antibiotics we use directly and indirectly are truly affecting us. Once we learn more about this impact, then we can start to make progress in influencing the development of new alternatives and better approaches to antibiotic usage.
Let’s step into a time machine for a moment. Acquire some plutonium, unlock the Delorean, rev it up to 88 miles per hour and we’re good to go. Destination: 1770.
The late 18th century was a pretty great place. Nations were being thought up and defended, women piled their hair into fantastic curly creations complete with white powder and men could sport walking sticks without looking like a try-hard hipster.
Sounds great right?
Unfortunately, it was also a time when the result of contracting a minor cold was often death.
Back to the future… (get it?).
This is the scenario (albeit somewhat exaggerated) that awaits us as a society if we do not tackle the problem of antibiotic resistance, according to the top health official in the UK.
Sallie Davies, chief medical officer for England, called for a global fight against microbial, or antibiotic, resistance, as well as a push to fill a drug “discovery void” to treat mutating superbug infections like MRSA, the National Post reported Wednesday.
According to the same report, new antibiotics are few and far between, and only a handful have been marketed in the past few decades. This means that when a new strain of resistant bacteria emerges, there is very little we can do to treat against it.
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Traditionally, disease has been presented as an army of creepily crawly microbes, lurking on every surface and wafting through the air, waiting to jump up onto our skin or sneak into our nostrils to infect us.
But in an eternally ironic twist of circumstances, the very thing that we use to fight off the bacterial invader might actually be our most fickle foe. According to the medical journel Lancet, antibiotic resistance is now “a global health concern.”
With friends like that, who needs enemies?
The increased exposure to all sorts of antibiotics in our everyday lives has made it so that bacteria that used to be wiped out by a dose of antibiotics have developed resistant strains.
One of the most common – and most serious – of these is Methicillin-resistant Staphylococcus aureus (MRSA), the resistant strain of the staph bacteria most commonly found in health-care settings. Read more »
Mentioning MRSA to someone outside of the medical field often elicits a blank stare or a vague look of confusion and mistrust. In fact, going so far as to mention Methicillin Resistant Staphylococcus Aureus (MRSA) is usually enough to end a conversation completely. For the most part, the destructive, life-altering scope of MRSA isn’t known to the general public—nor is the risk of acquiring MRSA in the hospital. Knowing many patients and health care workers, I’ve seen prognoses that have varied from life-threatening and permanently disabling, to non-deadly, but career ending. This is the story of two acquaintances of mine: one who contracted MRSA in the community at large, and another who contracted MRSA while at the hospital.
Down on her luck, living in a small, government subsidized apartment, my first acquaintance was forced to share her space with several other near-homeless individuals. Crowded in a tiny room, many of her roommates were poorly fed and suffered from mental illness. As is the case in many situations of extreme poverty, drug abuse and poor hygiene were rampant—as were skin infections. Such close-knit quarters were a breeding ground for CA-MRSA, or Community Acquired MRSA. Community Acquired MRSA differs, in that it’s a) often more aggressive b) less resistant to antibiotics than its hospital counterpart.
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In an attempt to find new ways to prevent cases of MRSA, researchers have been working to develop a new vaccine. Several pharmaceutical companies have attempted to create vaccines for MRSA in the past, but such endeavors have not been successful. The main reason for this is that it is not known what makes individuals immune to the disease. Current research into a MRSA vaccine is in the very early stages, and even if a successful vaccine was developed, it would take years to receive approval.
We often blog about the importance of preventing surgical site infections. An effective vaccine to combat MRSA would be a major milestone in the fight against antibiotic resistance. This is because powerful antibiotics are used to treat active MRSA infections, and each time such therapies are used, the more likely it becomes for the bacteria to develop resistance. Thus, the most optimal treatment would be to prevent MRSA before it occurs. If a successful vaccine was to be developed, it would likely be given prior to surgical procedures, and in those with compromised immune systems. But, why wait years for a MRSA vaccine to be developed when there are simple solutions available right now? Read more »
Over the coming year, the world will learn more about our MRSAid™ photodisinfection technology and its ability to prevent surgical site infections. The last patients in the year long quality improvement program at Vancouver General Hospital (VGH) will be treated next month, giving us a chance to look retrospectively at how surgical site infections were affected at this major hospital. This program, involving over 5,000 patients at VGH, sought to reduce infections in all patients undergoing cardio, vascular, neurological, thoracic, breast, spinal and orthopaedic surgeries. Data from this analysis is expected in the late fall and results are expected to be announced at Infection Control Conferences in 2013.
People who carry MRSA or MSSA are at much greater risk of self infection when they are immunocompromised and weakened after surgery. Up to 30% of patients are simply unable to defend themselves from the tenacious bacteria called Staphylococcus aureus which lie dormant in the nose, waiting for opportunities to invade the body. Eliminating the bacteria carried in the nose prior to surgery has been proven to reduce the rate of surgical site infections. From a number of other studies (including Bode et al “Preventing SSIs In Nasal Carriers of Staph”), we have learned that eliminating both MRSA and MSSA from the nose prior to surgery reduces surgical site infections (SSIs) by up to 56% and total healthcare-associated infections (HAIs) by up to 79% in non-surgical admissions.
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We’ve blogged in the past about MRSA being found on grocery meat in Detroit. Now, the same problem is occurring in Iowa, Minnesota, and New Jersey. A a recent study published this past January revealed that 64% of pork samples from grocery stores in these areas were contaminated with Staphylococcus aureus. Of these, more than 6% tested positive for MRSA, the drug-resistant strain of Staph.
Tara Smith, an epidemiologist at the University of Iowa and one of the study’s contributing authors notes the uncertainty of the source of contamination. The molecular typing from these samples are shown as a combination of both “human” and “pig” strains. This suggests that the bacteria may be from both the farm and the people who handle the products.
As most of you know, methicillin-resistant Staphylococcus aureus is one of the most deadly and resistant strains of Staph bacteria. According to the Centers for Disease and Control and Prevention, more than 90,000 people develop a serious MRSA infection every year and up to 20% of the infected population die. Of those that survive, many face incredibly difficult recovery periods that often involve more medication and surgery. Read more »
Our MRSAid™ Photodisinfection procedure has been well received at VGH and represents a promising approach to improve patient safety in other healthcare facility settings… Photodisinfection (is) ideal for hospital settings as it eliminates the need for patient compliance as it can be administered just prior to surgery- Carolyn Cross, Chairman and CEO of Ondine.
Less than a year ago, Vancouver General Hospital implemented the MRSAid™ Photodisinfection System as part of a year-long infection control Quality Improvement Project. Since then, we are very pleased to announce that we have treated over 2,500 patients, making this one of the largest PDT studies in the world. The project is being undertaken with the objective of reducing the incidence of surgical site infections in selected surgical populations.
Many people do not know that the nose is the primary site for bacteria colonization. The average person touches their nose more than 100 times a day, and if they touch their nose and then touch their surgical site, they are at risk of giving themselves an infection that was completely preventable. Many studies have demonstrated a significant reduction in surgical site infections after nasal decolonization of both Staph and MRSA. It is therefore critical to continue the development of non-antibiotic treatments that eliminate potentially deadly bacteria from the nose.
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There are several companies which offer rapid diagnostic tests for a drug-resistant staph infection known as MRSA (Methicillin-resistant Staphylococcus aureus), one of the most common superbugs found in hospitals. The Centers for Disease Control and Prevention (CDC) states that MRSA affects 90,000 Americans each year, killing about 18,000.
Rapid diagnosis of MRSA enables a healthcare facility to quickly determine if a new patient is colonized with MRSA and would enable intervention measures to be deployed more quickly. Rapid diagnosis is expected to therefore reduce the spread of MRSA to other patients via healthcare workers who are seen to be the usual vector of transmission across the healthcare facilities. Deployment measures would include isolation chambers, full gown & glove protocols, hand washing before and after patient visits etc. An additional use of MRSA diagnostics is the opportunity to apply intervention measures to prevent surgical site infections since MRSA carriers run the risk of self-infection once their bodies are immuno-compromised after a surgery.
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