More on Man’s Best Friend

Here’s an extraordinary video about a dog and his owner.

Maureen Burns had a lump in her breast and suspected cancer. However, two mammograms and a scan said she didn’t. But her dog Max, a red collie cross, was telling her something different. “He just wasn’t happy,” says Maureen. In fact, because Max was 9 ½ she thought she was losing him. Occasionally, though, Max would do something odd – he’d touch Maureen’s breast with his nose then back off “so desperately unhappy, such a sad look in his eyes.” Then one day it hit her. Staring into the mirror and looking at Max lying on her bed Maureen suddenly knew what Max was trying to tell her – she had cancer.

I’ll let her tell you the rest of the story:

As we reported last week the use of dogs for medical detective work has moved over into infectious disease as well. Notably, in the detection of the superbug C. difficile, a diarrhea-causing hospital superbug that kills 29,000 Americans every year. In principle, there’s no reason why this couldn’t be extended to other disease-causing superbugs such as MRSA.

In the latest development, scientists at the University of Arkansas, Little Rock, just reported that Frankie, a trained scent dog has successfully sniffed out thyroid cancer in people who had not yet been diagnosed with it.

Interestingly, the lab is also trying to find a new home for canine-veterans from Iraq and Afghanistan. Instead of sniffing out bombs, they will be trained to hunt for cancer.

Dog Detectives

dog detectiveMan’s best friend appears ready to do us another good turn.

Meet Angus, a 10 month old springer-spaniel puppy enrolled in Detective School over at Vancouver General Hospital. He’s learning how to sniff out the hospital superbug Clostridium difficile, or C difficile, before it gets hold of the patients.

The most prevalent of hospital superbugs, C difficile causes life-threatening diarrhea. It prefers the elderly, and once it gets hold of you it can return time and again, leaving you in a state of helpless anxiety between “cures.”

And there’s a lot of it. Just last week for example, a study conducted by the U.S. Centers for Disease Control and Prevention and published in the New England Journal of Medicine, concluded that C difficile causes almost 500,000 serious infections and 29,000 deaths a year.

Did you find those numbers meaningful? Because psychologists tell us that for most of us large numbers like that won’t sink in. So to get some perspective, let’s compare the harm caused by C difficile to the harm caused to U.S. troops during the Vietnam War. The total number of wounded was 153,303 and the number of deaths was 10,785 – and that was over a 20 year period that ended when the last helicopter pulled out of Saigon in 1975.

In other words, C difficile is serious business. Or as the CDC puts it, “This bacteria is an immediate public health threat that requires urgent and aggressive action.” (p.51)

The immediate threat exists mostly for hospital patients and the elderly in long term care facilities. One kind of aggressive action required is prevention – find the bug before it finds you. The trouble is, care homes and especially hospitals are large facilities. Invisible creatures can lurk anywhere, and there’s plenty of nooks and crannies to serve as hideouts. So how can we find them?

Angus! He has a nose for this kind of thing, literally. He has 125 to 300 million scent glands, while humans have a paltry 5 million or so. To appreciate the difference consider that, blindfolded, our sense of smell can detect the presence of an Olympic-size swimming pool. But a dog could find a single drop of water in 20 Olympic pools. And fortunately, diseases have specific scents associated with them too, which dogs can detect in such things as our breath, sweat, and urine.

We know that this heightened trait of smell is why we have long used our pals to detect such things as narcotics and bombs and to search for lost children. Now medical science has picked up the scent and has begun enlisting them as disease detectives. For example, about 10 years ago we saw the advent of medical assistance diabetic alert dogs to detect when a person’s blood sugar is low. Then we started programs using dogs in the early detection of various cancers, such as lung, ovarian, breast, bladder, and prostrate. And bringing us full circle, research published in the British Medical Journal 3 years ago found that dogs could sniff out C difficile with 100% accuracy. So Vancouver General Hospital is on to something here, and good for them.

Here’s a brief video where we meet Angus hard at work, as well as infectious disease specialist Elizabeth Bryce, MD, who is overseeing the program.

Antibiotics can not only make you sick, they can kill you. And a new report says they’re doing so at a rate far greater than we realized

Just Say No, unless your doctor is sure you need them

Just Say No … unless your doctor is sure you need them

An expansive study by the U.S. Centers for Disease Control and Prevention published in the New England Journal of Medicine on Wednesday tells us that the rate of death and infection caused by the bacterium Clostridium difficile, or C. diff, is actually about twice as much as we thought.

And what we thought was bad enough. As recent as the fall of 2013 the CDC released a report, “Antibiotic Resistant Threats in the United States,” that placed C. diff in its top category of dangerous pathogens because of its widespread harm. It killed about 14,000 Americans a year and seriously infected 250,000. Hence the CDC warning: “This bacteria is an immediate public health threat that requires urgent and aggressive action.”

We learned this week, however, that those 2013 C. diff numbers were a gross underestimate by half. The new report concludes that “C. diff was responsible for almost half a million infections and was associated with approximately 29,000 deaths in 2011.” (The last year for which we have data.)

Yet even these numbers underestimate the true extent of the harm because the researchers only counted deaths within 30 days of infection, and because they only counted the initial and 1 subsequent infection – there were 83,000 of those — in the same person. This matters because C. diff can return time and again. With each subsequent infection the disease is more severe thus harder to treat, and it becomes easier to transmit to others.

The study also raised 2 other concerns.

One, people over 65 catch C. diff at a rate 8 times greater than the general population.

Two, there’s a new strain of C. diff out there that’s more severe and easier to catch. The CDC’s Michael Bell, MD, explains: “In the past, patients infected with C. diff have had diarrhea related to antibiotic use that was often perceived as a nuisance, but not a major problem. Unfortunately, the type of C. diff circulating in the US today produces such a powerful toxin that can cause a truly deadly diarrhea. Patients receiving antibiotics are now at risk for not just mild diarrhea, but intense illness that can cause damage to the bowel so painful and severe that part of the colon needs to be surgically removed.”

This brings us to the heart of the problem. “Antibiotics are clearly driving this whole epidemic,” says Dr. Bell. It works like this. Your intestines contain millions of bacteria, many of which help protect your body from infection. But when you take an antibiotic to treat an infection, it can can destroy some of the normal, helpful bacteria as well as the bacteria causing the illness. Without enough healthy bacteria, C. diff can quickly grow out of control and become the dominant bacteria in your GI tract. They would be the majority bacteria in step 3, below.

abr 2

Margaret Riley, Ph.D., professor of biology at the University of Massachusetts, Amherst, offers an interesting analogy. She says taking an antibiotic is like ingesting a hydrogen bomb because it kills everything, all of your body’s bacteria, the good and the bad. In other words, antibiotics, she says, are not like a laser-guided missile that kill only the bad bacterial cells.

Sound familiar? Think cancer. Because in this sense the effect on your body of a course of antibiotics is similar to the effect of a course of radiation: in both cases you’re using a shotgun to kill a fly and so you end up with “collateral damage,” examples of which are well-known in the case of radiation therapy – hair loss, fatigue, decreased appetite, radiation sickness, and so on.

Now for the good news. You have a vital role to play in your own healthcare and you have more control than you may realize. In this context there’s a simple but important rule: Stop asking for antibiotics. That message comes direct from the Harvard School of Public Health at a public forum they held a year ago. It’s a patient-empowering discussion that we highly recommend.

When it Comes to Healthcare, Should Life Imitate Art?

We love our doctors and nurses.

You can see it in the annual polls that tell us they consistently rank at the very top of the professional heap (our friends in Congress, not so much). This reality is even reflected in our cultural narrative about them; for example, in how they’re portrayed on television. From Marcus Welby, MD, to George Clooney’s character Dr. Doug Ross on ER, to today’s Grey’s Anatomy, we are presented with a string of highly competent, caring, and properly motivated people.

But there’s a problem. The professional reputation of our best and brightest is taking a hit these days. The charge against them is that they’re over-prescribing antibiotics. This drives the emergence of resistant bacterial strains, which poses a serious threat to public health. In the words of the World Health Organization: “… the world is headed for a post-antibiotic era, in which common infections and minor injuries which have been treatable for decades can once again kill …” So much so, in fact, that a recent UK government-sponsored report predicts that deaths by antibiotic-resistant infections will surpass deaths caused by cancer by the year 2050.

So the trick is to cut back on prescribing unnecessary antibiotics, especially in those cases where we know they won’t work – e.g., for most colds and the flu – or for any other illegitimate reason.

Illegitimate reasons? Take a look at this survey conducted by the online journal Medscape, that tells us why clinicians – i.e., physicians, physician assistants, and nurse practitioners – prescribe antibiotics.

reasons for prescribing

That’s troubling stuff. Basing treatment decisions on patient demands or the fear of lawyers, for example, is not what we expect to see. It begs the question, where do we go from here?

And to help answer that, how wrong would it be to ask ourselves this – what would Dr. Doug Ross do?

Antibiotics and You: The Super Bowl Edition Featuring Katy Perry

Almost a year ago to the day, Stuart Levy, MD, a senior professor and researcher at the Tufts University School of Medicine, sat on a panel at the Harvard School of Public Health and told us what needs to be done to fight antibiotic resistance: “If I had $800,000 to spend on fighting infectious disease,” he said, “I’d spend $700,000 of it on educating the community: They need to be a partner in using antibiotics properly.”

Which begs the question: How, exactly, do you educate the public on a complex matter of science? Because for several years now the likes of the World Health Organization, the US Centers for Disease Control and Prevention, and even President Obama, have done their best to raise public awareness about our overuse of antibiotics, but seemingly to little or no avail.

So what’s Plan B? Take a look at this sexy ad from yesterday’s Super Bowl:

I’m sure Dr. Levy and his colleagues haven’t consider getting their message across in quite this way. But here’s the thing: it might just be working. The company that owns Carls Jr., the burger joint featured in the ad, told the Huffington Post that “sales of the burger have ‘exceeded projections’ since its debut six weeks ago.”

This matters because it’s the overuse of antibiotics that drives antibiotic resistance. And since about 80% of all antibiotic use in the US is for raising our food animals – cows, pigs, and chickens — demanding that they go antibiotic free is a big deal.

What’s more, the US Food and Drug Administration has come under heavy criticism for not policing the livestock producers for their inappropriate use of antibiotics. As the burger company puts it: “Your government is not going to protect you,” therefore, “The public is going to have to demand this for their own sake.”

Want to further increase the demand for burgers made from free-range, grass-fed cattle that are never exposed to antibiotics, steroids or added hormones? Unfortunately, repeatedly telling the public that in the US alone antibiotic resistant bacteria kill more than 23,000 people every year and seriously infect a further 2 million people seems to go only so far.

So how about this: Did you catch the acclaimed Super Bowl halftime show by pop icon Katy Perry? She happens to have more twitter followers that anyone on the planet: 64.5 million “KatyCats” follow her. She also happens to have a strong philanthropic bent that involves the health of children.

Dr. Levy said if he had $800,000 to spend on infectious disease that almost all of it – $700,000 – would go to making the public “a partner in using antibiotics properly.” And who better than Katy Perry to reach 64.5M people all at once?

So here’s the question: how many tweets would $700k buy?

MRSA: The Boomerang Bacteria

If you go to the hospital and happen to catch MRSA, the assumption is you will be treated for it and that will be the end of the story. Unfortunately, we’re learning that catching MRSA in the hospital is often just the beginning of the story, and not a pretty one at that. Specifically, “successfully” treated MRSA patients are almost 50% more likely to die in the year after their release from hospital compared to similar patients who never had MRSA.

This was the conclusion of a recent US study that followed the progress of 3,592 MRSA patients after they were released from hospital. They were matched to a second group of 3,592 patients, the difference being that these patients never had MRSA. The results: Patients with MRSA hospital-acquired infections (HAIs) were 49% more likely to die within a year of their release from hospital compared to the non-MRSA patients.

The researchers offer two reasons for this: “First, the increased risk of death may be caused by recurrent infections, which are common in patients with MRSA infection. Second, recent evidence suggests that Staphylococcus aureus HAIs can lead to long-term disabilities (e.g., chronic ventilator dependence, dialysis-dependent end-stage renal disease), which may also increase the risk of death.”

Moreover, death after discharge isn’t the only consequence of a MRSA HAI. For example, other studies have found with patients surviving to discharge, 1 in 4 will require multiple re-admissions for complications due to their MRSA infection. And surgery within 30 days as well as admission to an ICU were also associated with MRSA infection.

The results of the US study alone, say researchers, “underscore the importance of [hospital] interventions designed to reduce the transmission of MRSA and the need to consider long-term outcomes when evaluating the economic impact of such interventions.”

Here’s the thing: we know how to intervene. Take the case of Canada’s Vancouver General Hospital, who were determined to cut down on the number of infections associated with major surgery. So they engaged in a year-long non-antibiotic project – thus not contributing to the rising plague of antibiotic resistance – involving more than 5,000 surgical patients. Using a combination of photodisinfection technology and chlorhexidine wipes they reduced surgical site infections by 39% and the number of readmissions due to SSIs from 4 to 1.25 cases per month. Their effort saved the hospital more than $1 million in costs.

For this work they were awarded the Innovation Award of Excellence by the International Consortium for Prevention & Infection Control which is endorsed by the World Health Organization. And from BC Minister of Health Terry Lake they earned this accolade: “Congratulations to the Vancouver General Hospital team on this significant recognition of your work as leaders in the area of infection control. This achievement is a great example of how we are turning to innovation throughout the health system as a way of enhancing patient care and safety, while reducing costs.”

So we can do it that way. Or we can continue to send the MRSA-affected patients home … and wait for them, like MRSA itself, to come back.

The choice is ours.

How we think: “the death of one person is a tragedy; the death of one million is a statistic.”

We protect our emotional selves just as we do our physical selves. The surprising part, though, is the kind of thing that triggers this emotional self-preservation.

For example, the big news story lately about infectious disease is that by the year 2050 more people will die from drug-resistant infections than from cancer. The number of deaths is estimated to be around 10 million – each year.

Logic suggests that this is a compelling storyline and so we would want to know more and perhaps see if there’s something we could do to help. But psychologists tell us that just the opposite happens: “when the numbers [of dead or injured] go up, the amount of sympathy people feel goes perversely down. And with it goes the willingness to donate money or time to help.”

Psychologists call this the “collapse of compassion.” It means that “when people see multiple victims, they turn the volume down on their emotions for fear of being overwhelmed.”

So let’s test the theory by comparing our response to two bits of similar information and see which scenario collapses – or triggers – our compassion:

(1) Each year in the US more than 23,000 people die and over 80,000 are seriously infected by MRSA. Serious infection means things like multiple surgeries, the loss of a limb, excruciating pain, and lifelong scarring.

(2) A video (from Oprah Winfrey) of just one person – not 23,000 – who fell victim to MRSA.

Just how aggressive are bacteria? Watch them in action

We often think of bacteria as idle creatures. But here’s this neat video that shows them to be more like a hard-charging cavalry. After you watch it imagine that MRSA bacteria have gotten into your blood. And imagine what happens as your circulatory system drops off the MRSA at your body’s vital organs like your heart and lungs. That’s what they call sepsis, and it’s described as an “aggressive” infection. The video shows you why.

Dangerous Popsicles: Does a California artist know more about science education than scientists?

We humans like to think that we’re rational beings. That before we make an important decision we gather all the relevant facts and assemble them in some logically cohesive fashion. Alas, that is not always us.

The latest reminder of the folly of our ways comes to us from a study about our decision-making when it comes to taking antibiotics. They don’t work for viruses, which includes most colds, the flu, earaches, and bronchitis. So if your doctor tells you your sickness is viral-based, you’re not going to ask for an antibiotic are you? Well, more than half the people in that situation will. More surprising yet, doctors will go ahead and write the prescription simply because you asked for it – yikes. In other words, the message isn’t getting through.

So how are we to educate the public – and doctors – about this? A San Francisco artist, Wei Li, thought it would be a good idea to turn a yucky subject – MRSA, HIV, influenza, etc. – into something fun and familiar. Thus all the better for discussion and sharing of information. Ms. Li has designed a line of so-called “Dangerous Popsicles” – yes, we actually get to eat them! – that give new life to the hazardous bacteria, which normally infect our bodies, not delight our taste buds. Have a look at what she has done:

Dangerous Popsicles from Bold or Italic on Vimeo.

If this kind of thing raises awareness about infectious disease then more power to Ms. Li. Because as a recent report tells us, drug-resistant infections will outstrip cancer as a cause of death by 2050. But just because this is serious business, it doesn’t mean that learning about it has to be all business

So let’s talk about this stuff … and pass the popsicles please.

We’re Already There

Tom Frieden, MD, Director of the Centers for Disease Control and Prevention, addressed a gathering of journalists this summer at the National Press Club in Washington, DC. His concern is the rising plague of antibiotic resistance. These were his heartfelt words:

I’m an infectious disease physician. I’ve treated patients for many infections and I’ve also treated patients for whom there are no antibiotics left. I felt like a time traveler going back to an era before antibiotics. We talk about the pre-antibiotic era and the antibiotic era. If we’re not careful we’ll soon be in a post-antibiotic era. And, in fact, for some patients and some pathogens, we’re already there.

We’re already there for people like 19-year-old Jessica Petzold of Indiana. Though healthy at the time of Frieden’s talk, about one month ago on November 20 – a week before Thanksgiving – Jessica noticed a pimple on her face. It progressed swiftly to fever and joint pains then to a full blown MRSA infection in her bloodstream, lungs, and hips. Ten days later Jessica was dead.

“We were all just so dumbfounded and shocked when the doctors came and said, ‘There’s nothing else we can do,’” said her mother Lisa.

Despite their pain, Lisa and her husband Joe are reaching out to share their story. They don’t want what happened to them to happen to us. Here they are:

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