Photodisinfection is a topical, non-antibiotic antimicrobial therapy that destroys a broad spectrum of pathogens including fungi, bacteria and virus without damaging human tissue. Unlike antibiotics, Photodisinfection selectively kills virulence factors such as the endotoxins and exotoxins produced by pathogens, leading to a clinically observable anti-inflammatory effect. The treatment process takes only minutes, making it over 1,000 times more effective at biofilm killing than antibiotics.
Photodisinfection is a minimally invasive non-thermal therapy involving the light activation of a photosensitizer to eliminate topical infections in a highly targeted approach. Photodisinfection has been proven to be safe and effective in other applications such as for the dental, sinusitis and hospital acquired infection prevention markets. In dentistry, Photodisinfection has been proven to be highly effective for the treatment of caries, endodontics, restorative dentistry, periodontitis, peri-implantitis and halitosis. Many new applications of Photodisinfection are now under development.
The Photodisinfection Process: Instant Antimicrobial Therapy
Apply Photosensitizer to Infection Site & Illuminate with Appropriate Wavelength for Several Minutes
A photosensitizing solution is applied to the treatment site where the photosensitizer molecules preferentially bind to the targeted microbes. The photosensitizer molecules are inactive at this stage. A light of a specific wavelength and intensity illuminates the treatment site and a photocatalytic reaction occurs. The wavelength is carefully chosen to maximize absorption of light energy by the photosensitizer.
This 2 step procedure results in the destruction of the targeted microbes and their virulence factors without damaging host cells. This reaction involves the formation of short-lived, highly reactive free-radical oxygen species. These radicals cause a physical disruption of the microbial cell membrane through oxidative reactions, resulting in immediate rupture and destruction of the cell. This process occurs in seconds with total kills completed in minutes.
The Photodisinfection process has also been shown to eliminate a multitude of virulence factors, unlike antibiotics. When the light isremoved, the photocatalytic reaction ceases along with all antimicrobial action. Photodisinfection does not promote the development of resistance. The Photodisinfection process is both pain-free and stress-free due to lack of side-effects or damage to human tissue.
A few days ago, we announced an innovative partnership with one of Canada`s largest hospitals, Vancouver General Hospital (VGH). We are very excited to have this partnership featured on Global News.
Pathogenic bacteria such as Staphylococcus aureus and MRSA can significantly increase the risk of a patient developing serious infections after surgery. MRSAidTM is a non-antibiotic therapy designed to eliminate bacteria in the noses of patients during high infection risk times. As part of our partnership with VGH, MRSAidTM will be used on patients undergoing cardiac, spinal, breast reconstruction, thoracic, neurological, and orthopaedic surgeries. We are very excited to be working with the leaders in infection control at VGH. For more information on MRSAidTM, please visit www.mrsaid.com. Also, please connect with us on Twitter & Facebook, we`ll be happy to respond to any comments and questions.
Every year on April 7th, we celebrate World Health Day to mark the founding of the World Health Organization (WHO). Under this year’s theme of “Combating Drug Resistance,” the WHO is challenging healthcare professionals around the world to take action and implement change to address the growing problem of antibiotic resistance. Ondine is pleased to be able to respond to this challenge by entering into an innovative partnership with one of Canada’s largest hospital to introduce a novel non-antibiotic decolonization therapy aimed at reducing hospital-acquired infections (HAI’s).
Staphylococcus aureus, especially Methicillin-Resistant Staphylococcus aureus (MRSA), infections can be severe and even fatal. Each year, thousands of patients acquire Staph infections annually while in hospital resulting in enormous suffering, amputations and loss of life. Studies throughout North America and the UK have demonstrated that patients who are carrying or are colonized with Staphylococcus aureus are at risk of self-infecting. Studies also have demonstrated that eliminating nasal carriage of Staphylococcus aureus significantly reduces the number of Staph infections and therefore must be considered a necessary strategy for the overall reduction of healthcare-associated infections.1,2
The nose, armpits, hand and groin are the major hotspots for MRSA colonization
The light diffusing tip delivers light to the treatment area, powering the photodynamic reaction without heat or generating resistance
“There are two kinds of light — the glow that illumines, and the glare that obscures…”
In 1963, James Thurber was almost certainly unaware of photodynamic medicine when he authored that quote, or else he might have added a 3rd type of light – the glimmer that heals. Loosely put, the word photodynamic means using light to cause an action or effect. This definition, though simple, succinctly summarizes the concept of photodynamic medicine – a set of therapies that leverages visible light to create a targeted, potent effect. So how can simple light in the range of red to violet (the kind we can see) generate a clinical effect? Save for a select group of therapies, some more reputable than others, it cannot…on its own. Read More
Biofilm Stages of Development - Source: Wiki Commons
Humans are multicellular creatures each comprised of trillions of cells. Oddly enough, bacteria in our bodies outnumber our human cells by 10:1, although their size is, on average, about one tenth of a human cell. When seen in this light, humans really are part human and part bacteria. We are dependent on the maintenance of a delicate balance between human cells and bacterial cells for good health as we coexist with bacteria in a symbiotic relationship. There are estimated to be between 500-1,000 species of bacteria living in the human gut and skin. Some of our bacteria are known to perform certain tasks that are critical. Without our bacteria, for instance, we would be unable to digest and process our food intake. These commensal bacteria are widely known as our “flora”. Too many of any one kind of bacteria, and we are left in poor health. Bacteria, therefore, play a very important role in human health and human disease.